Understanding Cannabinoids

Science-based, accessible information about CBD, CBG, CBN, CBC, and the human endocannabinoid system. Written for patients, reviewed by healthcare professionals.

Informação baseada em ciência e acessível sobre CBD, CBG, CBN, CBC e o sistema endocanabinoide humano. Escrito para pacientes, revisado por profissionais de saúde.

What Are Cannabinoids?

Cannabinoids are natural compounds found in the Cannabis sativa plant. Hemp-derived cannabinoids interact with your body's own endocannabinoid system to support balance and wellness. The five cannabinoids Medicanna USA specializes in are:

Canabinoides são compostos naturais encontrados na planta Cannabis sativa. Os cinco canabinoides em que a Medicanna USA se especializa são:

CBD

Cannabidiol

Canabiodiol

The most researched cannabinoid. CBD is non-psychoactive and has been studied for anxiety, inflammation, sleep, and neuroprotection. It is the only cannabinoid with FDA-approved pharmaceutical applications (Epidiolex®).

O canabinoide mais pesquisado. Não é psicoativo e foi estudado para ansiedade, inflamação, sono e neuroproteção.

Common uses: Anxiety, chronic pain, epilepsy, inflammation, sleep
Usos comuns: Ansiedade, dor crônica, epilepsia, inflamação, sono
CBG

Cannabigerol

Canabigerol

Called the "mother of all cannabinoids" — all other cannabinoids start as CBG before enzymatic conversion. CBG is being researched for its antibacterial, anti-inflammatory, and neuroprotective properties, and may support focus and gut health.

Chamado de "a mãe de todos os canabinoides". Pesquisado por propriedades antibacterianas, anti-inflamatórias e neuroprotetoras.

Common uses: Focus, gut health, glaucoma, antibacterial support
Usos comuns: Foco, saúde intestinal, glaucoma, suporte antibacteriano
CBN

Cannabinol

Canabinol

A mildly psychoactive cannabinoid produced as THC ages. CBN is best known for its sedative properties and is studied as a sleep aid. It may also have antibacterial and anti-inflammatory effects.

Melhor conhecido por propriedades sedativas. Estudado como auxiliar do sono, com efeitos antibacterianos e anti-inflamatórios.

Common uses: Sleep support, mild sedation, antibacterial
Usos comuns: Apoio ao sono, sedação leve, antibacteriano
CBC

Cannabichromene

Cannabicromeno

One of the three most common cannabinoids, CBC does not bind strongly to CB1 or CB2 receptors but interacts with other pain-related receptors. Studied for analgesic, anti-inflammatory, and mood-supporting properties.

Estudado por propriedades analgésicas, anti-inflamatórias e de apoio ao humor. Não se liga fortemente aos receptores CB1 ou CB2.

Common uses: Pain, depression, neurogenesis support
Usos comuns: Dor, depressão, suporte à neurogenesis
CBDV

Cannabidivarin

Canabidivarina

A structural analog of CBD (propyl homolog). CBDV is currently in clinical trials for autism spectrum disorder and Rett syndrome. It has shown anticonvulsant properties and is non-psychoactive.

Análogo estrutural do CBD. Em ensaios clínicos para transtorno do espectro autista e síndrome de Rett. Propriedades anticonvulsivantes.

Common uses: Seizures, autism spectrum, neurological support
Usos comuns: Convulsões, espectro autista, suporte neurológico
FULL SPECTRUM

The Entourage Effect

O Efeito Entourage

Research suggests cannabinoids work synergistically — each enhancing the therapeutic effect of the others. Full-spectrum products preserve this natural synergy, while broad-spectrum removes THC but keeps all other cannabinoids.

Pesquisas sugerem que os canabinoides funcionam de forma sinérgica. Produtos full-spectrum preservam essa sinergia natural.

The Endocannabinoid System

The endocannabinoid system (ECS) is a complex cell-signaling system present in all mammals, including humans. Discovered in the early 1990s, it plays a key role in regulating a range of functions and processes including:

O sistema endocanabinoide (SEC) é um sistema complexo de sinalização celular presente em todos os mamíferos, incluindo humanos. Descoberto no início dos anos 1990, desempenha papel fundamental na regulação de diversas funções:

Sleep / Sono
Mood / Humor
Appetite / Apetite
Inflammation / Inflamação
Immune Response / Imunidade
Memory / Memória
Pain / Dor
Temperature / Temperatura

How the ECS Works / Como o SEC Funciona

1
Endocannabinoids Produced
Your body naturally produces cannabinoids (anandamide, 2-AG). / Seu corpo produz canabinoides naturalmente.
2
Bind to Receptors
CB1 receptors (brain/CNS) and CB2 receptors (immune/peripheral) receive these signals. / Receptores CB1 (cérebro/SNC) e CB2 (imunidade) recebem os sinais.
3
Plant Cannabinoids
Phytocannabinoids like CBD interact with these same receptors, mimicking or modulating your body's own signals. / Fitoanabinoides como CBD interagem com esses mesmos receptores.
4
Homeostasis
The result: regulation of mood, pain, sleep, and inflammation to restore balance. / O resultado: regulação do humor, dor, sono e inflamação para restaurar o equilíbrio.
Important: CBD does not directly bind to CB1/CB2 receptors the way THC does — it modulates the system indirectly, which is why it is non-psychoactive. / O CBD não se liga diretamente aos receptores CB1/CB2 como o THC — ele modula o sistema indiretamente, por isso não é psicoativo.

General Dosage Guide

Dosage varies by individual, condition, and product type. Always start low and go slow. Consult a physician before starting cannabinoid therapy, especially if taking medications.

A dosagem varia por indivíduo, condição e tipo de produto. Sempre comece devagar e aumente gradualmente. Consulte um médico antes de iniciar a terapia com canabinoides, especialmente se estiver tomando medicamentos.

Disclaimer: These are general guidelines only, not medical advice. Always follow your prescribing physician's instructions. / Estas são apenas diretrizes gerais, não conselho médico. Siga sempre as orientações do seu médico.
Condition / Condição Starting Dose / Dose Inicial Typical Range / Faixa Típica Product Type / Tipo Notes / Notas
Anxiety / Ansiedade 10–15mg CBD 20–60mg/day CBD Oil / Tincture Take AM + PM / Tomar manhã + noite
Chronic Pain / Dor Crônica 15–20mg CBD 30–100mg/day Oil, Topical / Óleo, Tópico Topical for localized relief / Tópico para alívio localizado
Sleep / Sono 15mg CBN 15–30mg CBN CBN Oil 30–60 min before bed / Antes de dormir
Epilepsy / Epilepsia Per physician / Por médico Highly variable CBD Oil / Óleo ANVISA prescription required / Prescrição ANVISA obrigatória
Inflammation / Inflamação 10mg CBD 20–50mg/day CBD + CBC Oil Combined CBD+CBC may enhance effect / CBD+CBC combinados
Focus / Foco 10mg CBG 10–40mg/day CBG Oil, Gummies Morning use preferred / Uso matinal preferível
Autism Spectrum / TEA Per physician / Por médico Highly variable CBDV Oil Requires specialist guidance / Requer orientação especializada

Sources: Project CBD, PubMed clinical reviews, ANVISA technical reports | Always titrate slowly. Individual responses vary significantly.

How to Read a Certificate of Analysis

A Certificate of Analysis (CoA) is a third-party laboratory document that verifies what is in a cannabinoid product. Every Medicanna USA batch has a public CoA. Here is how to verify it:

Um Certificado de Análise (CoA) é um documento de laboratório terceirizado que verifica o que há em um produto canabinoide. Cada lote da Medicanna USA possui um CoA público.

1
Find the QR Code or Lot Number

Every Medicanna USA product label has a batch/lot number and QR code linking directly to the CoA in our patient portal. / Cada rótulo Medicanna USA tem número de lote e QR code.

2
Verify the Lab is Accredited

Check that the testing laboratory is ISO/IEC 17025 accredited and independent from the manufacturer. / Verifique se o laboratório é acreditado pela ISO/IEC 17025 e independente do fabricante.

3
Check the Cannabinoid Panel

The potency panel shows exact mg/g concentrations of CBD, THC, CBG, CBN, CBC, and CBDV. Verify the label claim matches. / O painel de potência mostra as concentrações exatas de cada canabinoide.

4
Confirm THC is ≤0.3%

For legal hemp products in the USA and for ANVISA-authorized imports to Brazil, total THC must be ≤0.3%. / Para produtos legais nos EUA e importações ANVISA para o Brasil, o THC total deve ser ≤0,3%.

5
Check Pesticide & Heavy Metal Panels

All Medicanna USA CoAs include pesticide screening and heavy metal analysis. Results should show "ND" (Not Detected) or values below action limits. / Todos os CoAs incluem pesticidas e metais pesados.

6
Verify Test Date

CoAs should be dated within 12 months of purchase. Cannabinoid potency can degrade over time. / O CoA deve ser datado dentro de 12 meses da compra.

View Our Batch CoAs / Ver CoAs dos Lotes

Key Studies & References

Selected peer-reviewed publications and regulatory documents on cannabinoid science. / Publicações científicas revisadas por pares sobre a ciência dos canabinoides.

Devinsky O. et al. (2017)

NEJM — Trial of Cannabidiol for Drug-Resistant Seizures in Dravet Syndrome

Landmark RCT showing CBD significantly reduced seizure frequency vs placebo in patients with Dravet Syndrome. Led to FDA approval of Epidiolex.

View
Blessing EM. et al. (2015)

Neurotherapeutics — Cannabidiol as a Potential Treatment for Anxiety Disorders

Systematic review finding preclinical evidence strongly supports CBD as a treatment for multiple anxiety disorders.

View
Corroon J. & Phillips JA. (2018)

Cannabis and Cannabinoid Research — A Cross-Sectional Study of Cannabidiol Users

Survey of 2,409 CBD users showing the most common uses are self-treating anxiety, sleep disorders, and pain.

View
Dawidowicz AL. et al. (2021)

Molecules — The Effectiveness of CBD in Chronic Pain Management

Review of clinical trials demonstrating the analgesic potential of CBD-based treatments for chronic pain conditions.

View
ANVISA RDC 660 (2022)

Brazilian Health Regulatory Agency — Resolution for Cannabinoid Products

Brazilian regulation governing the authorization and import of cannabis-based products for individual medical use. Establishes the legal framework for patients to import from companies like Medicanna USA.

View
Medical Disclaimer / Aviso Médico: The information on this page is for educational purposes only and does not constitute medical advice. Cannabinoid therapy should always be supervised by a qualified physician. These statements have not been evaluated by the FDA. / As informações nesta página são apenas para fins educacionais e não constituem conselho médico.
Ready? / Pronto?

Start Your Cannabinoid Journey

Now that you understand the science, explore our products, find a doctor, or contact us for guidance.
Explore nossos produtos, encontre um médico ou entre em contato.

Get Wellness Tips & Exclusive Offers

Join patients and wellness advocates who trust Medicanna USA for certified quality cannabinoids.

No spam. Unsubscribe anytime. We respect your privacy.